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Our results pave the way for the AFM-indentation-based fabrication of plasmonic nanostructures with a highly precise size and shape controllability and reproducibility.In this study, fine hollow nanocapsules, consisting of NiFe hydroxides (denoted as H-NiFe(OH)x), are designed and synthesized for the delivery of an anticancer drug (Doxorubicin, DOX) and tumour depletion. Owing to its fascinating characteristics of "Fe2+ preservation and regeneration", H-NiFe(OH)x presents considerable Fenton activity for hydroxyl radical (˙OH) induction