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Thirteen volume data sets were segmented into native-space tissue probability data using SPM12. Examination of the 3D data without nonuniform signal intensity showed that significant differences in measured volumes were not observed on repeated analysis of variance, but examination of the 3D data with nonuniform signal intensity did show significant differences in measured volumes in gray matter and CSF but not in white matter. Measured volumes using segmented tissue probability data obtained using SPM12 were not influenced by the contra