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Building on these findings could be important for health and social care policy for marginalised groups.Background Transthoracic hybrid minimally invasive esophagectomy (HMIE) is frequently performed in patients with esophageal cancer. However, no conclusive benefit has been defined for HMIE compared with open esophagectomy (OE) or totally MIE (TMIE). The aim of this meta-analysis is to evaluate the effectiveness of HMIE compared with OE and TMIE.Methods PubMed, Embase (via OVID) and Cochrane databases were comprehensively searched for