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BACKGROUND At present, little is known about the genetic background of breast cancer (BC) in Kyrgyz. Therefore, the aim of this study was to assess gene-to-gene interactions and the contribution of p.Arg72Pro (TP53 gene), p.Gln399Arg (XRCC1 gene), p.Arg194Trp (XRCC1 gene), g.4682G A (TNFα gene), p.Val353Ala (HMMR gene), c.14 + 309 T G (MDM2 gene) and g.38444 T G (PALB2 gene) polymorphic loci in breast cancer (BC) risk in females of Kyrgyz ethnicity. METHODS The case-control study comprised 103 females with histologically