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Importantly, combining the novel quinolone ELQ-300 with atovaquone, ended up being synergistic against both species. Our data identify possibly essential species differences in proguanil susceptibility and its particular connection with quinolones, and support the ongoing development of novel quinolones as potent antimalarials that target multiple species. Copyright © 2020 American Society for Microbiology.Bacterial persisters are phenotypic variants that temporarily show an extraordinary toler