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To evaluate the efficacy of a mix of carboxymethylcellulose and glycerin (Optive®) after intra-vitreal injection therapy (IVT) with anti-vascular endothelial growth factor for reducing ocular discomfort in patients. We prospectively included patients who were naïve of any IVT. No artificial tear treatment was prescribed after the first IVT. After the second IVT, all patients instilled three drops per day of Optive® for 3 days. Every patient answered a questionnaire concerning the ocular discomfort at 72 hr after both IVTs and a questionnaire a