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Increased small-worldness related to worse WM accuracy in patients with more severe depression, anxiety and illness burden. Limitations We used only 2-back load, limiting our ability to study the parametric effects of task demand. Conclusions We demonstrate a putative state-dependent mechanistic link between connectome topology, hub re-distribution and impaired n-back performance in bipolar disorder. The aberrant task-dependent modulation of the connectome relates to worse WM performance especially when anxiety and depression are promin