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ign colectomy patients may benefit from extended VTE prophylaxis. Excessive exposure to fluoride can reduce intelligence. Methylenetetrahydrofolate dehydrogenase, cyclohydrolase, and formyltetrahydrofolate synthetase 1 ( MTHFD1 ) polymorphisms have important roles in neurodevelopment. However, the association of MTHFD1 polymorphisms with children's intelligence changes in endemic fluorosis areas has been rarely explored. A cross-sectional study was conducted in four randomly selected primary schools in Tongxu County, Henan Province, from