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This review aimed a better understanding of the uses of microalgae for new researches in nutrition. Because of the use of microalgae is still a field in which there is much to discover, it is likely that more benefits will be found in its consumption. Copyright© Bentham Science Publishers; For any queries, please email at [email protected] review summarizes the synthetic methodologies used in the last 25 years in the synthesis of chalcones, which are a class of flavonoids having a 1,3-diphenyl-2-propene-1-one backbone. These