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This work would provide a promising method for the application of MOFs to enhance the bio-/organic-fouling resistance of TFN membranes with high water permeation and salt rejection.Bottom-up mass spectrometry-based protein analysis methods employing protease digestion are routinely used to identify and characterize proteins with high specificity and sensitivity. Method performance is generally measured by sequence coverage capability and the total number of characteristic peptides identified, when compared to predicted databases. Limitat