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Our systematic study reveals how the loading condition dictates the formation of various instability modes including one-dimensional (1D) sinusoidal wrinkles, herringbone, labyrinth, and checkerboard.Techniques used to clear biological tissue for fluorescence microscopy are essential to connect anatomical principles at levels ranging from subcellular to the whole animal. Here we report a simple and straightforward approach to efficiently render opaque tissue samples transparent and show that this approach can be modified to rapidly labe