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ADHD Medication - Finding the Right One Finding the right ADHD medicine requires a lot of trial and error. Many factors affect effectiveness such as individual metabolism, side effects and how a drug interacts with other medications and supplements. It can take some time for stimulants to take effect, but they do improve concentration, attention and impulsivity. They also increase levels of brain chemicals, such as dopamine and epinephrine. Stimulants The stimulants, also referred to as uppers, boost the body's functions and make people feel more al