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In this paper, Fe3O4@ppy-Pt core-shell nanoparticles (NPs) could be produced and utilized for the development of a novel electrochemical sensor to detect 6-mercaptopurine (6-MP). 6-MP determination was examined by cyclic voltammetry (CV), chronoamperometry (CHA), linear sweep voltammetry (LSV), and differential pulse voltammetry (DPV) at Fe3O4@ppy-Pt core-shell NPs modified screen printed electrode (Fe3O4@ppy-Pt/SPE) in phosphate buffered solution (PBS). The outcomes obtained from DPV demonstrated that the Fe3O4@ppy-Pt/SPE proved a lin