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Furthermore, we conducted case studies in breast cancer, stomach cancer and colorectal cancer for further performance evaluation. CONCLUSION All the results show reliable prediction ability of SIMCCDA. We anticipate that SIMCCDA could be utilized to facilitate further developments in the field and follow-up investigations by biomedical researchers.BACKGROUND Initially characterized as axon guidance factors, semaphorins also have been implicated to have critical roles in multiple physiological and developmental functions, including the regulation of immune r