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To determine current prevalence and trends of pseudophakia in a well-defined U.S. population, calculating values for Olmsted County, Minnesota from 1988 through 2018. Mayo Clinic, Rochester, Minnesota. Population-Based Cohort Study. Rochester Epidemiology Project (REP) databases were used to identify all cases of pseudophakia in Olmsted County, Minnesota, between January 1, 1988, and December 31, 2018. Age- and sex-specific prevalence rates were calculated in 1988, 1998, 2008, and 2018 using REP census population estimates and mortality c