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Mixed surfactants have a prominent synergistic effect and show advantages in many aspects. In this work, the effects of a mixture of dodecyltrimethylammonium bromide (DTA and sodium dodecyl sulfate (SDS) on the flotation of low-rank coal were studied from the wetting rate, contact angle, surface tension, and zeta potential. Furthermore, the adsorption configuration of the mixed surfactant on the surface of oxygen-containing graphite was simulated at the molecular level by molecular dynamics simulation. The experimental resu