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Though it is actually named a cell area marker, the functional regulating functions of CD44 continue to be elusive. Here we report the breakthrough that CD44 mediates the endocytosis of iron-bound hyaluronates in tumorigenic cellular lines, major disease cells and tumours. This glycan-mediated metal endocytosis apparatus is improved during epithelial-mesenchymal transitions, in which iron runs as a metal catalyst to demethylate repressive histone scars that regulate the phrase of mesenchymal genetics. CD
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