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14-1.27]) and stroke (systolic BP, per 10 mm Hg OR, 1.35 [95% CI, 1.24-1.48]; diastolic BP, per 5 mm Hg OR, 1.20 [95% CI, 1.12-1.28]). Nonlinearity Mendelian randomization test demonstrated linear causal association of BP with these outcomes. Consistent estimates were observed in sensitivity analyses, suggesting robustness of the associations and minimal horizontal pleiotropy. The linear positive causal association of BP and CVD was consistent with previous findings that lower BP is better, thus consolidating clinical knowledge on hyper