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Conclusion Together, our data suggest that impaired lipophagy, ER stress and increased cholesterol synthesis lead to LD accumulation and hepatic steatosis. V-ATPase assembly defects are thus a novel form of hereditary liver disease with implications for the pathogenesis of non-alcoholic fatty liver disease. This article is protected by copyright. All rights reserved.OBJECTIVE Osteoclasts are responsible for bone destruction in rheumatoid arthritis (RA), and adipose-derived mesenchymal stromal cells (ADSCs) can inhibit expe