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ration of an H S supplement. Vascular disease is associated with marked changes in the -sulfhydration of endothelial cell proteins involved in mediating responses to flow. Short-term H S supplementation improved vascular reactivity in humans highlighting the potential of interfering with this pathway to treat vascular disease. Vascular disease is associated with marked changes in the S-sulfhydration of endothelial cell proteins involved in mediating responses to flow. Short-term H2Sn supplementation improved vascular reactivity in humans