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Finally, the increase in PMCA4 protein levels induced by testosterone was prevented by pre‑treatment with the AR antagonist flutamide. The present results confirmed that PMCA4 was upregulated during mouse testis development and that PMCA4 mRNA and protein expression levels were regulated by androgens and AR. The present findings suggest that PMCA4 may be involved in the regulation of spermatogenesis.The tumour suppressor gene F‑box and WD repeat domain‑containing 7 (FBXW7) plays an important role in human cancer by regulating cell divis
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