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Almost all of the molecular biomarkers in RP are immunological biomarkers, with autoantibodies and proteins related to cartilage damage within the bloodstream being the most frequent. Alterations in some genes (HLA typing and UBA1 somatic mutation) were detected in customers with RP, that could act as a potential biomarker for the diagnosis of RP. Furthermore, proinflammatory cytokine and lymphocyte levels, and specific laboratory examinations, have specific values of RP diagnosis and disease acti