https://www.selleckchem.com/pr....oducts/mptp-hydrochl
an, Iran, and Institut Pasteur in Paris, France. The authors declare no competing interests. N/A. N/A.Biallelic Parkin (PRKN) mutations cause autosomal recessive Parkinson's disease (PD); however, the role of monoallelic PRKN mutations as a risk factor for PD remains unclear. We investigated the role of single heterozygous PRKN mutations in three large independent case-control cohorts totalling 10 858 PD cases and 8328 controls. Overall, after exclusion of biallelic carriers, single PRKN mutations were more common in PD than
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