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o determine the transfer, metabolism and toxic effects of this diverse class of substances, on the human term placenta. Over the recent years, the role of trimethylamine N-oxide (TMAO) as a gut-derived metabolite mediating cardiovascular disease pathogenesis has been under particularly intense scrutiny. The aim was to explore whether TMAO levels were associated with clinical severity or functional outcome in Chinese patients with ischemic stroke. This is a single-center, prospective cohort study from Xiamen, China. We examined the relati