https://www.selleckchem.com/pr....oducts/molidustat-(b
Rates of fluoride elimination and iodination of the Breslow intermediate (BI) derived from 2-(1-hydroxy-2,2,2-trifluoroethyl)-thiamin provide a quantitative assessment of competing reactions at C2α of the BI. The competition probes the intrinsic reactivity of this important class of intermediates. Fluoride elimination, which occurs upon formation of the BI, produces 2-(2',2'-difluoroacetyl)-thiamin, while the rate of iodination of the same BI provides a basis for estimating the rate of the competing protonation. The resu
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