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In this case report, a patient who had a large sacral pressure ulcer present for over 16 years with two exposed spinal segments and exposed peritoneum was treated with the hybrid-scale fiber matrix. A total of nine applications of the material were applied over 11 weeks. The wound demonstrated significant healing, wound exudate was notably reduced, and no complications were observed. New epithelial tissue formation, tissue coverage over the exposed bone, infection management, and wound exudate reduction were observed to the extent that the patient w