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This study aimed to investigate whether weekend admission was associated with a higher risk of 90-day mortality in patients with sepsis. This population-based cohort study was based on health records from the National Health Insurance Service database in South Korea. All adult patients (age≥18years) admitted for sepsis (A40, A41) or septic shock (R65.2) as diagnosed according to the International Classification of Diseases, 10th revision codes, during 2010-2018 were screened. Weekend admission was defined as admission for sepsis on weeken