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Psychometric properties were evaluated using confirmatory factor analysis (CFA). Higher mean WHODAS-2 scores were reported by those with anxiety, mood, and personality disorders ( 0.001) compared to other psychopathologies. The measure showed good internal consistency (global score α = 0.88; domain subscores α = 0.59 to 0.85) and acceptable goodness of fit indices in CFA confirming the original structure of WHODAS-2. Findings from this large-scale study could assist clinicians in interpreting WHODAS-2 scores in psychiatric populatio