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The writers talk about the effectiveness of widely used oral medicaments such as for example voltage-gated calcium channels antagonists, voltage-gated sodium channel antagonists, serotonin-norepinephrine reuptake inhibitors, NMDA antagonists, and medications with other systems of action. A lot of the presented medications were more effective than placebo; however , when comparing to each other, none of them had been signifbe taken into account whe