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With an aging population, the prevalence of osteoporosis is on the increase. Although advances in the field have made progress in focusing on the mechanisms regarding the condition, the efficacy of current treatments remains minimal and it is complicated by unexpected complications. Consequently, to conquer this therapy gap, brand new methods are needed to recognize and elucidate the mobile systems mediating the pathogenesis of osteoporosis, which calls for a strong knowledge of bone biology. This ch