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92 95% CI [3.0-11.8] p0.001); family stress increased risk for persistent anxiety (RR 1.71 95% CI [1.1-2.7] p=0.027). We find evidence of a direct effect of early depression (T1) on later family stress (T2); and early family stress (T1) on later anxiety (T2). We used screening measures of depression and anxiety rather than clinical interviews. Studies which focus only on late pregnancy may underestimate risk. Early identification, in the first trimester, is critical for prevention and treatment. Partner and family stressors are a ke