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Although air travel is perceived to be a risk factor for sickling complications, only 18% of HCPs recommend supplemental oxygen. Most HCPs advise patients to increase hydration, carry analgesics, and wear warm clothes to prevent sickling complications. The patient survey was limited by a low response rate. The majority of HCPs are not routinely recommending prophylactic oxygen to patients with SCD during air travel. The majority of HCPs are not routinely recommending prophylactic oxygen to patients with SCD during air travel. High-flow n