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Results We discovered that CIH enhanced migration of macrophages, and this effect was attenuated by exogenous ghrelin. Additionally, the facilitative effectation of CIH on migration of macrophages ended up being enhanced or reduced by upregulation or downregulation of ROCK2, respectively. This phenomenon suggested that ROCK2 ended up being taking part in CIH-induced migration in macrophages. Furthermore, western blot and transwell assays showed that ghrelin inhibited CI