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The increase in prevalence could be explained by a better prenatal diagnosis (ultrasonography). Holoprosencephaly has a low frequency in Chile and is associated to trisomy 13. The increase in prevalence could be explained by a better prenatal diagnosis (ultrasonography). Early diagnosis is fundamental in patients with Parkinson's disease (PD) to improve their quality of life. To determine the latency in the diagnosis of Parkinson's disease (PD) after the onset of motor symptoms. Prospective study carried out during 16 months in a publi