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Mechanically, P7C3-A20 stimulated fibroblast growth factor 21 (FGF21) and FGF1 via activating liver kinase B1 (LKB1) and AMP-activated protein kinase (AMPK), which further resulted in a reduced nuclear translocation of CREB regulated transcription coactivator 2 (CRTC2). In AMPKα2 knockout mice, the protection of P7C3-A20 against HFD-induced metabolism abnormities and fat accumulation, as well as the elevation of blood FGF21 and FGF1, were abolished. P7C3-A20 increased the gut microbiota species richness. Moreover, it enhanced the propor
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