https://www.selleckchem.com/pr....oducts/Idarubicin.ht
Insulin secretion significantly decreased after treatment by senescent microvesicles (P3 1.7 ± 0.2 vs untreated islet 2.7 ± 0.2, P .05) without altering the islet viability (89.47% ± 1.69 vs 93.15% ± 0.97) and with no significant apoptosis. Senescent microvesicles significantly doubled the expression of p53, p21, and p16 (P .05), whereas young microvesicles had no significant effect. Pro-senescent endothelial microvesicles specifically accelerate the senescence of islets and alter their function. These data suggest that isl
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