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5%) and required multiple drainage methods before cranioplasty. These were not associated with a protracted course or increased risk of death (P 0.05). Early bone flap restoration with simultaneous drainage was independently associated with earlier resolution of EACs (β= 0.56, P0.001). Systematic review confirmed lack of standardized direction with respect to EAC management. Our analyses reveal 2 clinically relevant phenotypes of EAC complicated and uncomplicated. Our proposed treatment algorithm involves replacing the bone fla
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