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This review presents the last decade of studies on the synthesis of various types of small-molecule inhibitors of the p53- Mouse double minute 2 homolog (MDM2) protein-protein interaction. The main focus is placed on synthetic approaches to such molecules, their cytotoxicity, and MDM2 binding characteristics.Objective To investigate the reasons for the diagnostic delay of juvenile Huntington's disease patients in the Netherlands. Methods This study uses interpretative phenomenological analysis. Eligible participants were parents and car