https://mdm2-receptor.com/inde....x.php/shuttle-suture
MLL is a target of chromosomal translocations in severe leukemias with bad prognosis. The common MLL fusion lover AF9 (MLLT3) can right bind to AF4, DOT1L, BCOR, and CBX8. To delineate the relevance of BCOR and CBX8 binding to MLL-AF9 for leukemogenesis, here we determine protein structures of AF9 buildings with CBX8 and BCOR, and show that binding of all of the four partners to AF9 is mutually exclusive. With the structural analyses, we identify point mutations that selectively di
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