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Here, we prove that nicotinamide, a vitamin B3 and class III histone deacetylase inhibitor, dramatically improves delayed tooth eruption in Runx2 +/- mice, a well-known CCD animal model, through the renovation of decreased osteoclastogenesis. We also found that Csf1 mRNA and necessary protein amounts had been substantially reduced in Runx2 +/- osteoblasts as compared with wild kind whereas RANKL and OPG levels had no factor between crazy type and Runx2 +/- osteoblasts. Th

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