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001) enamel demineralization occurred over time within each group. There were significant between-group differences in the changes that occurred in area (P=0.004), impact (P=0.022), but not intensity. The 12-week had significantly larger areas of demineralization than the 6-week (P=0.041) and 4-week (P=0.001) groups. Changes in impact was significantly (P=0.007) greater in the 12-week group than 4-week group, but not greater than the 6-week group. There were no statistically significant differences between 4- and 6-week groups in the chan

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