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Approximately 58% of the studies did not externally validate the models. For clinical application, LTG maintenance dose could be optimized using population pharmacokinetic models employing covariates such as concomitant antiepileptic drugs, body weight, and genetic polymorphisms. However, these models should be assessed for their predictability in the target population before utilizing such models in clinical settings. For clinical application, LTG maintenance dose could be optimized using population pharmacokinetic models employing cova