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oliferation. Finally, circ_0003865 silencing repressed OP development in mouse model. MEL promotes BMSC osteogenic differentiation and inhibits OP pathogenesis by suppressing the expression of circ_0003865, which regulates GAS1 gene expression via sponging miR-3653-3p. MEL promotes BMSC osteogenic differentiation and inhibits OP pathogenesis by suppressing the expression of circ_0003865, which regulates GAS1 gene expression via sponging miR-3653-3p.Pain is a common non-motor symptom of Parkinson's disease (PD), with current limited knowl