https://www.selleckchem.com/pr....oducts/indoximod-nlg
Deleting both and results in kidney agenesis, defects in NPC proliferation, and cell death. Deleting one copy of reversed the effect of deleting one copy of , which rescued the renal agenesis due to loss of and . SPRY1 expressed in NPCs modulates the activity of FGF signaling and regulates NPC stemness. These findings indicate the importance of the balance between positive and negative signals during NPC maintenance. SPRY1 expressed in NPCs modulates the activity of FGF signaling and regulates NPC stemness. These findings ind
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