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Objective To assess the association between ibuprofen use and the systemic inflammatory biomarkers C-reactive protein (CRP) and interleukin-6 (IL-6) in chronic Spinal Cord Injury (SCI).Study design Prospective cohort study.Setting Community dwelling individuals with SCI.Participants 338 (278 male, 60 female) community dwelling individuals with chronic SCI (≥1-year post-injury).Interventions None.Main outcome measures CRP and IL-6 levels were quantified by ultra-sensitive ELISA assay. General linear models were used to assess association