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AIMS/INTRODUCTION Pancreatic islets are heterogenous. To clarify the relationship between islet heterogeneity and incretin action in the islets, we studied gene expression and metabolic profiles of non-large and enlarged islets of the ZFDM rat, an obese diabetes model, as well as incretin-induced insulin secretion (IIIS) in these islets. MATERIALS AND METHODS Pancreatic islets of control (fa/+) and fatty (fa/fa) rats at 8 and 12 weeks of age were isolated. The islets of fa/fa rats at 12 weeks of age were separated into non-large islets (
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