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The long-term use of Chlorhexidine (CHG) at high concentrations has detrimental effects on health and the environment. This research was aimed to evaluate the antibacterial capacity of CHG in the presence of choline as a natural additive to reduce the amount CHG required for the activity. The newly obtained formulation was evaluated for its stability and efficiency under physicochemical stresses. The checkerboard test was also performed to evaluate the type of CHG-additive interaction in a combinational state. The MIC of CHG was reduced u
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