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We have previously shown that high-dose constant infusion of recombinant human erythropoietin (rEPO) from 30min to 72 h after asphyxia in preterm fetal sheep reduced histological injury and improved electrophysiological recovery. This study shows that a high-dose infusion of rEPO from 6 to 72h after asphyxia did not improve EEG recovery, oligodendrocyte and neuronal survival at 1week post-asphyxia. Of concern, intermittent rEPO boluses started 6h after asphyxia were associated with impaired EEG recovery and bilateral cystic injury of te