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l cortex induced an enhancement of dopamine release. Collectively, these data suggest that this natural compound, through its multi-target activity is able to i) ameliorate behavioral alterations (i.e. depression), ii) selectively normalize cortical GABA levels, iii) rescue the impaired neuronal activity in the prefrontal cortex. Copyright © 2020 Boccella, Iannotta, Cristiano, Iannotti, Bello, Guida, Belardo, Infantino, Ricciardi, Giannella, Calignano, Di Marzo, Maione and Luongo.Aim The variable mechanisms on additive and synergistic
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