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Nuclear receptors control the transcriptional program of target cells and thereby their phenotype and activities. Two complementary studies by Micheals et al. (https//doi.org/10.1084/jem.20201311) and Chan et al. (https//doi.org/10.1084/jem.20200318) published in JEM uncover the cell type-specific expression and role of the nuclear receptors liver X receptors in the regulation of T cell homeostasis and function. Intraoperative neurophysiological monitoring of the motor pathways during epilepsy surgery is essential to safely achieve max